6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride

Names

[ Name ]:
6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride

[Synonym ]:
Benzothiazole, 6-[4-(4-methyl-2-thiazolyl)-1H-imidazol-5-yl]-, hydrochloride (1:1)
6-[4-(4-Methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole hydrochloride (1:1)
MFCD32633583

Biological Activity

[Description]:

TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)[1].

[Related Catalog]:

Research Areas >> Endocrinology

[References]

[1]. Takumi Naruse, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 May;69(3):485-491.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₁ClN₄S₂

[ Molecular Weight ]:
334.847

[ Exact Mass ]:
334.011353