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TRi-1(TXNRD1 inhibitor 1)

Names

[ CAS No. ]:
246020-68-8

[ Name ]:
TRi-1(TXNRD1 inhibitor 1)

Biological Activity

[Description]:

TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 12 nM (TXNRD1)[1].


[References]

[1]. Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H9ClN2O5S

[ Molecular Weight ]:
328.73

[ Storage condition ]:
2-8℃

Related Compounds