Thalidomide-PEG5-NH2
Names
[ CAS No. ]:
2460263-40-3
[ Name ]:
Thalidomide-PEG5-NH2
Biological Activity
[Description]:
Thalidomide-PEG5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
[Related Catalog]:
[Target]
Cereblon
[In Vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C23H31N3O9
[ Molecular Weight ]:
493.51
Safety Information
[ Hazard Codes ]:
Xi