Tetra(cyanoethoxymethyl) methane

Names

[ CAS No. ]:
2465-91-0

[ Name ]:
Tetra(cyanoethoxymethyl) methane

[Synonym ]:
MFCD00053281

Biological Activity

[Description]:

Tetra(cyanoethoxymethyl) methane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.13g/cm3

[ Boiling Point ]:
610.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₄N₄O₄

[ Molecular Weight ]:
348.39700

[ Flash Point ]:
232ºC

[ Exact Mass ]:
348.18000

[ PSA ]:
132.08000

[ LogP ]:
1.69392

[ Vapour Pressure ]:
7.54E-15mmHg at 25°C

[ Index of Refraction ]:
1.479

Tetra(cyanoethoxymethyl) methane

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds