PCSK9 modulator-4

Names

[ CAS No. ]:
2476490-20-5

[ Name ]:
PCSK9 modulator-4

Biological Activity

[Description]:

PCSK9 modulator-4 (Compound 21) is a potent modulator of PCSK9 with an EC50 value of 0.15 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-4 has the potential for the research of hyperlipidemia[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[References]

[1]. Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H11F2N3O

[ Molecular Weight ]:
311.29

Related Compounds