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Thalidomide-5-propargyne-NH2 hydrochloride

Names

[ CAS No. ]:
2490402-62-3

[ Name ]:
Thalidomide-5-propargyne-NH2 hydrochloride

Biological Activity

[Description]:

Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H14ClN3O4

[ Molecular Weight ]:
347.75

[ Storage condition ]:
2-8°C

Related Compounds