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SPIRAMYCIN I

Names

[ CAS No. ]:
24916-50-5

[ Name ]:
SPIRAMYCIN I

[Synonym ]:
9-O-[(2R,5S,6R)-5-(Dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]-leucomycin V
Foromacidine A
MFCD01314545
Spiramycin A
SPIRAMYCIN I STANDARD
Leucomycin V,9-o-((2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl)
Spiramycin-I
EINECS 232-429-6
Foromacidin A
Spiramycin I
demycarosylturimycin H

Biological Activity

[Description]:

Spiramycin I, isolated from Streptomyces ambofaciens, is a macrolide antibiotic and antiparasitic[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Zhu P, et al. Hydroxylation and hydrolysis: two main metabolic ways of spiramycin I in anaerobic digestion. Bioresour Technol. 2014 Feb;153:95-100.

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
913.7ºC at 760mmHg

[ Melting Point ]:
134-137ºC

[ Molecular Formula ]:
C42H72N2O14

[ Molecular Weight ]:
843.05300

[ Flash Point ]:
506.4ºC

[ Exact Mass ]:
842.51400

[ PSA ]:
195.38000

[ LogP ]:
2.32510

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WG9405000
CHEMICAL NAME :
Spiramycin A
CAS REGISTRY NUMBER :
24916-50-5
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C43-H74-N2-O14
MOLECULAR WEIGHT :
843.19
WISWESSER LINE NOTATION :
T-17-OV LU NUTJ DQ EO1 HVH J1 Q1 KO- FT6OTJ B1 CN1&1& FO- BT6OTJ CQ DN1&1 F1 EO- FT6OTJ B1 C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1010 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,604,1967

Safety Information

[ Hazard Codes ]:
N

Precursor & DownStream

Precursor

DownStream

Related Compounds