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LC kinetic stabilizer-1

Names

[ CAS No. ]:
2495750-19-9

[ Name ]:
LC kinetic stabilizer-1

Biological Activity

[Description]:

LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL* and WIL-FL* T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Yan NL, et al. Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site. Bioorg Med Chem Lett. 2022;60:128571.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H31N5O3

[ Molecular Weight ]:
473.57

Related Compounds