Polyethylene glycol diamine

Names

[ Name ]:
Polyethylene glycol diamine

[Synonym ]:
α,ω-Diamino Poly(Ethylene Glycol)
MFCD00132004
Poly(ethylene glycol) diamine
H2N-PEG-NH2
Polyethylene glycol diamine
Poly(ethylene glycol) bis(amine)

Biological Activity

[Description]:

PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Han X, et al. 9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitro. Int J Pharm. 2009 May 8;372(1-2):125-31.

Chemical & Physical Properties

[ Density]:
1.003g/cm3

[ Boiling Point ]:
241ºC at 760mmHg

[ Molecular Formula ]:
(C₂H₄O)nC₄H₁₂N₂O

[ Molecular Weight ]:
1000(Average)

[ Flash Point ]:
>110℃

[ Exact Mass ]:
148.12100

[ PSA ]:
70.50000

[ LogP ]:
0.33760

[ Appearance of Characters ]:
Granular Solid | White to off-white

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble in organic solvents. | It is soluble in organic solvents. It is insoluble in water.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H317-H318-H334

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R36/37/38;R42/43

[ Safety Phrases ]:
22-24/25-45-36/37-26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Synthesis of semitelechelic maleimide poly(PEGA) for protein conjugation by RAFT polymerization.

Biomacromolecules 10(7) , 1777-81, (2009)

Maleimide end functionalized polymers for site-selective conjugation to free cysteines of proteins were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization. A fura...

Construction of highly glycosylated mucin-type glycopeptides based on microwave-assisted solid-phase syntheses and enzymatic modifications.

J. Org. Chem. 71(8) , 3051-63, (2006)

A MUC1-related glycopeptide having five core-2 hexasaccharide branches (C330H527N46O207, MW = 8450.9) was synthesized by a new strategy using a combination of microwave-assisted solid-phase synthesis ...

Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B.

J. Med. Chem. 45(10) , 1971-82, (2002)

A one-bead-two-compound inhibitor library was synthesized by the split-mix method for the identification of inhibitors of a recombinant cysteine protease from Leishmania mexicana, CPB2.8DeltaCTE. The ...