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NNC 63-0532

Names

[ CAS No. ]:
250685-44-0

[ Name ]:
NNC 63-0532

[Synonym ]:
Tocris-1780
HMS3268G04
Salvinorin A

Biological Activity

[Description]:

NNC63-0532 is a novel non-peptide nociceptin receptor (ORL1) agonist, with EC50s of 305?nM. NNC63-0532 plays important roles in many disorders such as pain, drug addiction[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[References]

[1]. C Thomsen, et al. (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. Br J Pharmacol. 2000 Nov;131(5):903-8.  

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
645.8ºC at 760mmHg

[ Molecular Formula ]:
C27H29N3O3

[ Molecular Weight ]:
443.53700

[ Flash Point ]:
344.4ºC

[ Exact Mass ]:
443.22100

[ PSA ]:
53.09000

[ LogP ]:
3.59450

[ Vapour Pressure ]:
1.44E-16mmHg at 25°C

[ Index of Refraction ]:
1.675

[ Storage condition ]:
-20°C

Related Compounds