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Methyldopate hydrochloride

Names

[ CAS No. ]:
2508-79-4

[ Name ]:
Methyldopate hydrochloride

[Synonym ]:
METHYLDOPATE HYDROCHLORIDE
Methyldopa ethyl hydrochloride
EINECS 219-720-3
Methyldopa ethyl ester hydrochloride
UNII-7PX435DN5A

Biological Activity

[Description]:

Methyldopate hydrochloride is an ethyl ester hydrochloride prodrug of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate hydrochloride has the potential for severe hypertension research[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[References]

[1]. P D Walson, et al. Metabolic disposition and cardiovascular effects of methyldopate in unanesthetized rhesus monkeys. J Pharmacol Exp Ther. 1975 Oct;195(1):151-8.

Chemical & Physical Properties

[ Density]:
1.243g/cm3

[ Boiling Point ]:
398ºC at 760 mmHg

[ Molecular Formula ]:
C12H18ClNO4

[ Molecular Weight ]:
275.72900

[ Flash Point ]:
194.5ºC

[ Exact Mass ]:
275.09200

[ PSA ]:
92.78000

[ LogP ]:
2.42310

[ Vapour Pressure ]:
6.62E-07mmHg at 25°C

[ Index of Refraction ]:
1.572

Related Compounds