Thymidine,5'-amino-5'-deoxy-

Names

[ Name ]:
Thymidine,5'-amino-5'-deoxy-

[Synonym ]:
5'-Amino-5'-deoxy-D-thymidine
5'-amino-3'-hydroxythymidine
5'-amino-5'-deoxy-thymidine
5'-deoxy-5'-aminothymidine
5'-deoxy-5'-amino-deoxythymidine

Biological Activity

[Description]:

5′-Amino-5′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.394 g/cm3

[ Molecular Formula ]:
C₁₀H₁₅N₃O₄

[ Molecular Weight ]:
241.24

[ Exact Mass ]:
241.10600

[ PSA ]:
110.34000

[ Index of Refraction ]:
1.565

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Measurement of carbamoylating activity of nitrosoureas and isocyanates by a novel high-pressure liquid chromatography assay.

Biochem. Pharmacol. 35(14) , 2359-65, (1986)

A new assay for carbamoylating activity using reversed phase liquid chromatography (HPLC) is described which offers several advantages over existing assays. A comparison was made of the extent of carb...

Novel acyclic amide-conjugated nucleosides and their analogues.

Nucleosides Nucleotides Nucleic Acids 28 , 103-117, (2009)

An effective one-step synthesis of new amide-conjugated nucleosides and their analogues, in the presence of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) as the condensin...

Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas and corresponding phenyl isocyanates to 5'-amino-5'-deoxythymidine: importance of carbamoylation in mouse skin carcinogenic processes.

Carcinogenesis 13(4) , 699-702, (1992)

Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas (I-X: X = -OCH3, -CH3, -H, -Cl, and -COCH3) and of their corresponding phenyl isocyanates (II-X: X = -OCH3, -CH3, -H, -Cl and -COCH3) to the...