HIV-1 protease-IN-5

Names

[ CAS No. ]:
2525173-96-8

[ Name ]:
HIV-1 protease-IN-5

Biological Activity

[Description]:

HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC50 of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease

[Target]

IC50: 1.64 nM (HIV-1 protease)[1]


[References]

[1]. Zhu M, et al. Design and biological evaluation of novel HIV-1 protease inhibitors with isopropanol as P1' ligand to enhance binding with S1' subsite. Bioorg Med Chem. 2020 Aug 15;28(16):115623.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H29F3N2O7S

[ Molecular Weight ]:
582.59

Related Compounds