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MrgprX2 antagonist-5

Names

[ CAS No. ]:
2527815-74-1

[ Name ]:
MrgprX2 antagonist-5

Biological Activity

[Description]:

MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

MrgprX2[1]


[In Vitro]

MRGPRX2, a member of the Mas-related gene family, was found to be expressed in sensory neurons, mast cells and, most recently, in keratinocytes. MRGPRX2 mRNA is present in adipose tissue, esophagus, urinary bladder, lungs with the highest levels found in skin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions[2].

[References]

[1]. BIGI S, et, al. 3-amino-4h-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of mrgx2. WO2020223255A1.

[2]. Porebski G, et, al. Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions. Front Immunol. 2018 Dec 20;9:3027.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H13ClF2N4O2S

[ Molecular Weight ]:
434.85

Related Compounds