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N3-PEG3-CH2CH2-Boc

Names

[ CAS No. ]:
252881-73-5

[ Name ]:
N3-PEG3-CH2CH2-Boc

[Synonym ]:
tert-butyl 12-azido-4,7,10-trioxadodecanoate
tert-butyl 12-azido-4,7,10-trioxadocecanoate
12-azido-4,7,10-trioxadodecanoic acid tert-butyl ester
3-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester
N3-PEG3-CH2CH2COOtBu

Biological Activity

[Description]:

N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Yongxin Robert ZHAO, et al. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers. WO2018086139A1.

[2]. Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10(5):767-772.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H25N3O5

[ Molecular Weight ]:
303.35500

[ Exact Mass ]:
303.17900

[ PSA ]:
103.74000

[ LogP ]:
1.53106

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds