N-(2,5-Dihydroxybenzoyl)glycine

Names

[ Name ]:
N-(2,5-Dihydroxybenzoyl)glycine

[Synonym ]:
Gentisuric acid
Gentisuric Acid
N-(2,5-Dihydroxybenzoyl)glycine
2,5-Dihydroxyhippuric acid
2,5-Dihydroxybenzoyl-N-glycine

Biological Activity

[Description]:

Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316)[1][2].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. DeBlassio JL, et al. Amidation of salicyluric acid and gentisuric acid: a possible role for peptidylglycine alpha-amidating monooxygenase in the metabolism of aspirin. Arch Biochem Biophys. 2000 Nov 1;383(1):46-55.

[2]. Niikawa M, et al. Suppressive effect of post- or pre-treatment of aspirin metabolite on mitomycin C-induced genotoxicity using the somatic mutation and recombination test in Drosophila melanogaster. Biomed Pharmacother. 2007 Feb-Apr;61(2-3):113-9.

Chemical & Physical Properties

[ Density]:
1.532g/cm3

[ Boiling Point ]:
530.1ºC at 760mmHg

[ Molecular Formula ]:
C₉H₉NO₅

[ Molecular Weight ]:
211.17

[ Flash Point ]:
274.4ºC

[ Exact Mass ]:
211.04800

[ PSA ]:
106.86000

[ LogP ]:
0.30310

[ Vapour Pressure ]:
4.58E-12mmHg at 25°C

[ Index of Refraction ]:
1.643

MSDS

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Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2918290000

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%