TGFβRI-IN-5

Names

[ CAS No. ]:
2541690-15-5

[ Name ]:
TGFβRI-IN-5

Biological Activity

[Description]:

TGFβRI-IN-5 (Compound 4b) is a potent inhibitor of TGFβRI with an IC50 of 0.08 μM. TGFβRI-IN-5 displays amazing anticancer activity 5–7 times that of reference drug against all the tested cell lines. TGFβRI-IN-5 enhances apoptosis and arrested G2/M phase of cell cycle[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Ismail MMF, et al. Design and synthesis of novel tranilast analogs: Docking, antiproliferative evaluation and in-silico screening of TGFβR1 inhibitors. Bioorg Chem. 2020;105:104368.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H12N2O6

[ Molecular Weight ]:
328.28

Related Compounds