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PEG3-bis(phosphonic acid)

Names

[ CAS No. ]:
254762-10-2

[ Name ]:
PEG3-bis(phosphonic acid)

[Synonym ]:
Phosphonic acid, [oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis-
MFCD00778114
[Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(phosphonic acid)

Biological Activity

[Description]:

PEG3-bis(phosphonic acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
588.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H20O9P2

[ Molecular Weight ]:
322.186

[ Flash Point ]:
309.5±32.9 °C

[ Exact Mass ]:
322.058258

[ LogP ]:
-4.65

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.501

Related Compounds