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Lacto-N-fucopentaose III

Names

[ CAS No. ]:
25541-09-7

[ Name ]:
Lacto-N-fucopentaose III

[Synonym ]:
LNFP III
lacto-n-Fucopentaose III
Lewis-X pentasaccharide
4)-D-Glc
Lex-lactose

Biological Activity

[Description]:

Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH)
Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> Arginase

[In Vitro]

Lacto-N-fucopentaose III glycan (LNFP-III; 50 μg/mL; 48 h) 诱导炎症单核细胞产生一氧化氮。Lacto-N-fucopentaose III 减少树突状细胞跨脑内皮的迁移[1]。 Lacto-N-fucopentaose III glycan (50 μg/mL; 48 h) 显著增加精氨酸酶 I (Aldh1a2)、醛脱氢酶 1、A2 亚家族 (Aldh1a2)、吲哚胺 2,3-双加氧酶 1 (Ido1) 和血红素加氧酶 1 (Homx1) mRNA的表达[1]。

[In Vivo]

Lacto-N-fucopentaose III glycan (50 μg/mouse; i.v.; twice a week for 2 weeks) 显著降低实验性自身免疫性脑脊髓炎 (EAE) 和中枢神经系统炎症的严重程度，并扭曲小鼠对 Th2 显性谱的外周免疫反应[1]。 Lacto-N-fucopentaose III (35 μg dextran conjugate/mouse; s.c.; daily for 2 weeks) 改善 Gulf War Illness 小鼠模型的急性和持续性海马突触可塑性和传递缺陷[2]。

[References]

[1]. Zhu B, et al. Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis. Clin Immunol. 2012 Mar;142(3):351-61.  

[2]. Brown KA, et al. Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model. Life Sci. 2021 Aug 15;279:119707.  

Chemical & Physical Properties

[ Density]:
1.71g/cm3

[ Boiling Point ]:
1264.6ºC at 760 mmHg

[ Molecular Formula ]:
C32H55NO25

[ Molecular Weight ]:
853.77

[ Flash Point ]:
718.6ºC

[ Exact Mass ]:
853.30600

[ PSA ]:
415.62000

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.655

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds