Diflorasone

Names

[ Name ]:
Diflorasone

[Synonym ]:
(6a,11b,16b)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16β)-
(6S,8S,9S,10S,11S,13S,14S,16S,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
6a,9a-Difluoro-16b-methyl-d-1,4-pregnadiene-11b,17a,21-triol-3,20-dione
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Diflorasone
(6α,11β,16β)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
diflorasonum [INN_la]
flumetasone
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
6a,9a-Difluoro-16b-methylprednisolone
flumethasone

Biological Activity

[Description]:

Diflorasone is a potent topical anti-inflammatory steroid.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Wickrema Sinha AJ, et al. Percutaneous absorption and excretion of tritium-labeled diflorasone diacetate, a new topical corticosteroid in the rat, monkey and man. J Invest Dermatol. 1978 Dec;71(6):372-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
569.8±50.0 °C at 760 mmHg

[ Melting Point ]:
228-239ºC

[ Molecular Formula ]:
C₂₂H₂₈F₂O₅

[ Molecular Weight ]:
410.452

[ Flash Point ]:
298.4±30.1 °C

[ Exact Mass ]:
410.190491

[ PSA ]:
94.83000

[ LogP ]:
1.61

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.579

[ Storage condition ]:
Refrigerator

Safety Information

[ HS Code ]:
2937229000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2937229000