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KUC-7322

Names

[ CAS No. ]:
255734-04-4

[ Name ]:
KUC-7322

Biological Activity

[Description]:

KUC-7322, a selective β3 -adrenoceptor agonist, is the active form of ritobegron. Ritobegron decreases intravesical pressure with minimal effects on the cardiovascular system.

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Metabolic Disease

[References]

[1]. Igawa Y, Schneider T, Yamazaki Y, et al. Functional investigation of β-adrenoceptors in human isolated detrusor focusing on the novel selective β3-adrenoceptor agonist KUC-7322. Naunyn Schmiedebergs Arch Pharmacol. 2012;385(8):759-767.

[2]. Abe Y, Nakano Y, Kanazawa T, Furihata T, Endo T, Kobayashi M. Investigation of Drug-Drug Interactions Between Ritobegron, a Selective β3 -Adrenoceptor Agonist, With Probenecid in Healthy Men. Clin Pharmacol Drug Dev. 2016;5(3):201-207.

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
615.3ºC at 760mmHg

[ Molecular Formula ]:
C21H27NO5

[ Molecular Weight ]:
373.44300

[ Flash Point ]:
325.9ºC

[ Exact Mass ]:
373.18900

[ PSA ]:
99.02000

[ LogP ]:
3.11750

[ Vapour Pressure ]:
5.36E-16mmHg at 25°C

[ Index of Refraction ]:
1.592

Related Compounds