CYP3A4-IN-3

Names

[ CAS No. ]:
2562384-19-2

[ Name ]:
CYP3A4-IN-3

Biological Activity

[Description]:

CYP3A4-IN-3 is a high-affinity specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.075 μM. CYP3A4-IN-3 is a ritonavir analogue, but with a simpler structure and twice the inhibitory effect of ritonavir. CYP3A4-IN-3 is used as an antiviral agent and immunosuppressant[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Inflammation/Immunology

[Target]

CYP3A4:0.075 μM (IC50)


[References]

[1]. Eric R Samuels, et al. An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg Med Chem. 2020 Mar 15;28(6):115349. doi: 10.1016/j.bmc.2020.115349. Epub 2020 Jan 31.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H39N3O3S

[ Molecular Weight ]:
569.76

Related Compounds