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Annexin A1 (1-11) (dephosphorylated) (human, bovine, chicken, porcine) trifluoroacetate salt

Names

[ CAS No. ]:
256447-08-2

[ Name ]:
Annexin A1 (1-11) (dephosphorylated) (human, bovine, chicken, porcine) trifluoroacetate salt

[Synonym ]:
AC-ALA-MET-VAL-SER-GLU-PHE-LEU-LYS-GLN-ALA-TRP-OH
ANXA-1
ANNEXIN 1
AC-AMVSEFLKQAW
Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp

Biological Activity

[Description]:

Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vivo]

Ac2-12 (i.v.; 6.7 mg/kg, ≈70 nmol per mouse), was found to mimic the actions of lipocortin 1 (LC1) and Ac2-26 in male Swiss Albino mice (10-15 g)[1]. Ac2-12 (100 μg) significantly reduces polymorphonuclear leukocyte (PMN) influx in wild-type C57BL/6 mice and is no longer active in FPR KO mice[2].

[References]

[1]. L H Lim, et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14535-9.

[2]. M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158(6):1969-73.

Chemical & Physical Properties

[ Molecular Formula ]:
C63H94N14O17S

[ Molecular Weight ]:
1351.57000

[ Exact Mass ]:
1350.66000

[ PSA ]:
525.13000

[ LogP ]:
3.83750

Related Compounds