<Suppliers Price>

Tauro-β-muricholic acid

Names

[ CAS No. ]:
25696-60-0

[ Name ]:
Tauro-β-muricholic acid

[Synonym ]:
Tauro-β-muricholic Acid
Tauro-Beta-muricholic Acid

Biological Activity

[Description]:

Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> FXR
Research Areas >> Metabolic Disease

[Target]

40 μM (FXR)[1]


[References]

[1]. Denk GU, et al. Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential. Biochem Biophys Res Commun. 2012 Aug 10;424(4):758-64.  

[2]. Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17(2):225-35.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H45NO7S

[ Molecular Weight ]:
515.70300

[ Exact Mass ]:
515.29200

[ PSA ]:
152.54000

[ LogP ]:
3.83980

Related Compounds