NH-bis-PEG3

Names

[ CAS No. ]:
25743-12-8

[ Name ]:
NH-bis-PEG3

[Synonym ]:
3,6,12,15-Tetraoxa-9-azaheptadecane-1,17-diol

Biological Activity

[Description]:

NH-bis-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₂₇NO₆

[ Molecular Weight ]:
281.34600

[ Exact Mass ]:
281.18400

[ PSA ]:
89.41000

NH-bis-PEG3

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds