Ethofumesate

Names

[ Name ]:
Ethofumesate

[Synonym ]:
ethofumesate [ANSI, WSSA]
ETHOSIN
T56 BOT&J CO2 D1 D1 GOSW1
(RS)-2-ethoxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulfonate
Ethofumesate
EINECS 247-525-3
2-Ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl methanesulfonate
ETHOSAT
Nortran
NORTRON
2-Ethoxy-2,3-dihydro-3,3-dimethyl-5-benzofuranyl methanesulfonate
2-ethoxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate
(±)-2-Ethoxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate
rac-(2R)-2-ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl methanesulfonate
5-Benzofuranol, 2-ethoxy-2,3-dihydro-3,3-dimethyl-, methanesulfonate
2-ethoxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulfonate
2-Ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofur-5-yl methansulfonat
Nortranese
Ethofumesat
TRAMAT
Prograss
2,3-dihydro-3,3-dimethyl-2-ethoxybenzofuran-5-yl methanesulphonate
Norton
5-Benzofuranol, 2-ethoxy-2,3-dihydro-3,3-dimethyl-, methanesulfonate, (±)-
(±)-2-Ethoxy-2,3-dihydro-3,3-dimethyl-5-benzofuranol methanesulfonate
MFCD00055321
Caswell No. 427BB
2-Ethoxy-2,3-dihydro-3,3-dimethyl-5-benzofuranol methanesulfonate
Méthanesulfonate de 2-éthoxy-3,3-diméthyl-2,3-dihydro-1-benzofur-5-yle
NC 8438

Biological Activity

[Description]:

Ethofumesate, a chiral herbicide, acts by inhibiting mitosis and reducing photosynthesis and plant respiration[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Perovani IS, et al. Enantioselective in vitro metabolism and in vitro-in vivo correlation of the herbicide ethofumesate in a human model. J Pharm Biomed Anal. 2020;187:113349.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
409.1±45.0 °C at 760 mmHg

[ Melting Point ]:
100ºC

[ Molecular Formula ]:
C₁₃H₁₈O₅S

[ Molecular Weight ]:
286.344

[ Flash Point ]:
201.2±28.7 °C

[ Exact Mass ]:
286.087494

[ PSA ]:
70.21000

[ LogP ]:
2.00

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.546

[ Storage condition ]:
0-6°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF7716500

CHEMICAL NAME :: 5-Benzofuranol, 2-ethoxy-2,3-dihydro-3,3-dimethyl-, methanesulfonate, (+-)-

CAS REGISTRY NUMBER :: 26225-79-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H18-O5-S

MOLECULAR WEIGHT :: 286.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB85-143766

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A184,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A184,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A184,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 30,23,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

[ Symbol ]:

GHS09

[ Hazard Statements ]:
H411

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
N

[ Risk Phrases ]:
R51/53

[ Safety Phrases ]:
S61

[ RIDADR ]:
UN 3077 9/PG 3

[ RTECS ]:
DF7716500

[ Packaging Group ]:
III

[ HS Code ]:
2932999015

Customs

[ HS Code ]: 2932999015

[ Summary ]:
2932999015 2-ethoxy-3,3-dimethyl-2,3-dihydrobenzofuran-5-yl methanesulfonate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:13.0%。MFN tarrif:6.5%。general tariff:20.0%

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The fate of five herbicides (glyphosate, glufosinate-ammonium, phenmedipham, ethofumesate and metamitron) was studied in two Finnish sugar beet fields for 26 months. Soil types were sandy loam and cla...

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