HDAC1/6-IN-1

Names

[ CAS No. ]:
2630989-02-3

[ Name ]:
HDAC1/6-IN-1

Biological Activity

[Description]:

HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC6:13 nM (IC50)

HDAC1:89 nM (IC50)


[References]

[1]. Zheng H, et al. Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents. Bioorg Med Chem. 2022 Jan 1;53:116524.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H45N7O4

[ Molecular Weight ]:
591.74

Related Compounds