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Rhodojaponin III

Names

[ CAS No. ]:
26342-66-5

[ Name ]:
Rhodojaponin III

[Synonym ]:
Rhodoislandin B
Rhodojaponin-III
Grayanotoxane-5,6,10,14,16-pentol, 2,3-epoxy-, (2β,3β,6β,14S)-
(2β,3β,6β,14R)-2,3-epoxygrayanotoxane-5,6,10,14,16-pentol
Rhodojaponin III
(2β,3β,6β,14S)-2,3-Epoxygrayanotoxane-5,6,10,14,16-pentol

Biological Activity

[Description]:

Rhodojaponin III is a diterpenoid from the leaves of Rhododendron molle with anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Zhou J, et al. Anti-inflammatory Grayanane Diterpenoids from the Leaves of Rhododendron molle. J Nat Prod. 2018 Jan 26;81(1):151-161.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
557.3±50.0 °C at 760 mmHg

[ Melting Point ]:
285-287 °C

[ Molecular Formula ]:
C20H32O6

[ Molecular Weight ]:
368.465

[ Flash Point ]:
290.9±30.1 °C

[ Exact Mass ]:
368.219879

[ PSA ]:
113.68000

[ LogP ]:
1.09

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.632

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PB9225000
CHEMICAL NAME :
7,9a-Methano-9aH-cyclopenta(b)heptalene-4,8,11,11a,12 (1H)-pentol, 2,3-epoxydodecahydro-1,1, 4,8-tetramethyl-, (2R,3S,3as,4R,4ar,7R,8R,9as,11R,11aR,12R)-
CAS REGISTRY NUMBER :
26342-66-5
LAST UPDATED :
199806
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H32-O6
MOLECULAR WEIGHT :
368.52
WISWESSER LINE NOTATION :
T G3 E5 B765 A 1B Q BX HOTJ AQ DQ EQ F1 F1 KQ K1 PQ P1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 35,303,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
140 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 44,259,1980

Related Compounds