MK-0159

Names

[ Name ]:
MK-0159

Biological Activity

[Description]:

MK-0159 (compound 37) is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Metabolic Disease

[Target]

IC50: 3 nM (mouse CD38), 22 ± 5 nM (hCD38), 70 nM (rat CD38)[1]

[References]

[1]. Lagu B, et al. Orally Bioavailable Enzymatic Inhibitor of CD38, MK-0159, Protects against Ischemia/Reperfusion Injury in the Murine Heart. J Med Chem. 2022 Jun 28.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄N₄O₃S

[ Molecular Weight ]:
400.49

MK-0159

Names

Biological Activity

Chemical & Physical Properties

Related Compounds