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PROTAC EZH2 Degrader-1

Names

[ CAS No. ]:
2641601-67-2

[ Name ]:
PROTAC EZH2 Degrader-1

Biological Activity

[Description]:

PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Signaling Pathways >> PROTAC >> PROTAC

[Target]

EZH2:2.7 nM (IC50)


[References]

[1]. Juan Xia, et al. Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure-Activity Relationships Insights and Evolution Prospects. J Med Chem. 2022 May 26;65(10):7016-7043.

Chemical & Physical Properties

[ Molecular Formula ]:
C54H67N7O8

[ Molecular Weight ]:
942.15

Related Compounds