Thalidomide-NH-PEG7

Names

[ Name ]:
Thalidomide-NH-PEG7

Biological Activity

[Description]:

Thalidomide-NH-PEG7 is a synthesized E3 ligase ligand-linker conjugate for ADC. Thalidomide-NH-PEG7 can be connected to the ligand for protein by a linker to form PROTAC iRucaparib-AP6, a highly specific PARP1 degrader[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[References]

[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec;15(12):1223-1231.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₉N₃O₁₁

[ Molecular Weight ]:
581.61

Safety Information

[ Hazard Codes ]:
Xi

Thalidomide-NH-PEG7

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds