<Suppliers Price>

SSR 146977

Names

[ CAS No. ]:
264618-44-2

[ Name ]:
SSR 146977

Biological Activity

[Description]:

SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a Ki of 0.26 nM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

NK3


[References]

[1]. Emonds-Alt X, et, al. Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can J Physiol Pharmacol. 2002 May;80(5):482-8.  

Chemical & Physical Properties

[ Density]:
1.26

[ Molecular Formula ]:
C35H42Cl2N4O2

[ Molecular Weight ]:
621.64

[ Storage condition ]:
Store at +4°C

Related Compounds