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MRS 1754

Names

[ CAS No. ]:
264622-58-4

[ Name ]:
MRS 1754

[Synonym ]:
MRS 1754 hydrate
MRS 1754
ML 9 hydrochloride
Lopac-M-6316

Biological Activity

[Description]:

MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease
Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

A2B Adenosine Receptor[1]


[In Vitro]

The most potent displacer of [3H]MRS 1754 binding is MRS 1754. The Ki value for displacement of [3H]MRS 1754 binding to human A2B receptors expressed in HEK-293 cell membranes is 1.45±0.21 nM[1].

[References]

[1]. Ji X, et al. [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochem Pharmacol. 2001 Mar 15;61(6):657-63.

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Molecular Formula ]:
C26H26N6O4

[ Molecular Weight ]:
486.52200

[ Exact Mass ]:
486.20200

[ PSA ]:
134.80000

[ LogP ]:
3.33548

[ Storage condition ]:
2-8℃

Safety Information

[ Safety Phrases ]:
22-24/25

Related Compounds