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KRAS G12D inhibitor 16

Names

[ CAS No. ]:
2648221-12-7

[ Name ]:
KRAS G12D inhibitor 16

Biological Activity

[Description]:

KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12D:0.7 nM (IC50)


[In Vitro]

KRAS G12D inhibitor 16 has inhibitory activity for G12 with an IC50 value of 0.7 nM[1]. KRAS G12D inhibitor 16 shows growth inhibition activity KRAS-G12D mutant cell line (A-427) with an IC50 value of 0.35 μM[1].

[References]

[1]. Yuichi Kawai, et al. A compound having inhibitory activity against kras g12d mutation. Patent. WO2021107160A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H39IN6O3

[ Molecular Weight ]:
682.59

Related Compounds