Clathrin-IN-2

Names

[ CAS No. ]:
2650733-69-8

[ Name ]:
Clathrin-IN-2

Biological Activity

[Description]:

Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC50 value of 2.3 μM. Clathrin-IN-2 also has inhibitiory for dyn I GTPase with an IC50 value of 7.7 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease
Signaling Pathways >> Cytoskeleton >> Dynamin

[In Vitro]

Clathrin-IN-2 (Compound 8a) 可以抑制网格蛋白介导的内吞作用，IC50 值为 2.3 μM[1]。 Clathrin-IN-2 对 dyn I GTPase 具有抑制作用，IC50 值为 7.7 μM[1]。

[References]

[1]. Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H18Br2N2O

[ Molecular Weight ]:
426.15

Related Compounds