Ryuvidine

Names

[ Name ]:
Ryuvidine

[Synonym ]:
Ryuvidine

Biological Activity

[Description]:

Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 µM and suppresses monomethylation of H4K20 in vitro[1]. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM and is cytotoxic against a range of human cancer cells[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK4:6.0 μM (IC50)

[References]

[1]. Ryu CK, et al. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4.

[2]. Blum G, et al. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem Biol. 2014 Nov 21;9(11):2471-8.

Chemical & Physical Properties

[ Density]:
1.416g/cm3

[ Boiling Point ]:
463.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₂N₂O₂S

[ Molecular Weight ]:
284.33300

[ Flash Point ]:
234.3ºC

[ Exact Mass ]:
284.06200

[ PSA ]:
87.30000

[ LogP ]:
3.20790

[ Vapour Pressure ]:
8.83E-09mmHg at 25°C

[ Index of Refraction ]:
1.707