Endovion

Names

[ Name ]:
Endovion

[Synonym ]:
Urea,N-(3,5-bis(trifluoromethyl)phenyl)-N'-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)
UNII-943YH53W21
NS 3728

Biological Activity

[Description]:

Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel

Research Areas >> Others

[Target]

Chloride channel, VRAC/VSOAC[1]. ANO1[2].

[References]

[1]. Sørensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73.

[2]. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₉BrF₆N₆O

[ Molecular Weight ]:
495.18

[ Exact Mass ]:
493.99300

[ PSA ]:
99.08000

[ LogP ]:
5.39740

[ Storage condition ]:
2-8℃