1-Vinyl-4-methoxy-β-carboline

Names

[ Name ]:
1-Vinyl-4-methoxy-β-carboline

[Synonym ]:
1-Vinyl-4-methoxy-β-carboline
9H-Pyrido[3,4-b]indole, 1-ethenyl-4-methoxy-
dehydrocrenatine
HMS2271N07
TOB-10
Dehydrocrenation
4-Methoxy-1-vinyl-9H-β-carboline

Biological Activity

[Description]:

Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell Apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Research Areas >> Neurological Disease

Signaling Pathways >> MAPK/ERK Pathway >> JNK

Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Ho HY, et al. Apoptotic effects of dehydrocrenatidine via JNK and ERK pathway regulation in oral squamous cell carcinoma. Biomed Pharmacother. 2021 May;137:111362.

[2]. Hsieh MC, et al. Dehydrocrenatidine extracted from Picrasma quassioidesinduces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways. Oncol Rep. 2021 Aug;46(2):166.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
461.2±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₂N₂O

[ Molecular Weight ]:
224.258

[ Flash Point ]:
151.1±17.0 °C

[ Exact Mass ]:
224.094955

[ PSA ]:
37.91000

[ LogP ]:
3.79

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.737

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%