Perivine

Names

[ Name ]:
Perivine

[Synonym ]:
2,6-Methano-1H-azecino[5,4-b]indole-14-carboxylic acid, 5-ethylidene-2,3,4,5,6,7,8,9-octahydro-8-oxo-, methyl ester, (2S,5E,6R,14S)-
2,6-methano-1H-azecino[5,4-b]indole-14-carboxylic acid, 5-ethylidene-2,3,4,5,6,7,8,9-octahydro-8-oxo-, methyl ester, (2S,5E,6R)-
3-oxo-22-nor-vobasan-17-oic acid methyl ester
X1201
Methyl (1S,14R,15E,18S)-15-ethylidene-12-oxo-10,17-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraene-18-carboxylate
Methyl (1S,14R,15E)-15-ethylidene-12-oxo-10,17-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraene-18-carboxylate
Vobasan-17-oic acid,4-demethyl-3-oxo-,methyl ester
Perivin
3-Oxo-22-nor-vobasan-17-saeure-methylester

Biological Activity

[Description]:

Perivine (Perivin) targets protein retinoblastoma-associated proteins (RbAp48) and resolves the instability of the RbAp48-FOG-1 complex. Perivine can be used for the study of Alzheimer's disease[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

IC50: Retinoblastoma-associated proteins (RbAp48)[1]

[In Vitro]

Retinoblastoma-associated proteins (RbAp48) are related to Alzheimer's disease (AD), RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription. However, this is an unstable complex may affect the function of RbAp48. Perivine has a greater stable affinity for RbAp48 binding than FOG1, it might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy[1].

[References]

[1]. Hung-Jin Huang, et al. Lead Discovery for Alzheimer's Disease Related Target Protein RbAp48 From Traditional Chinese Medicine. Biomed Res Int

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
541.1±50.0 °C at 760 mmHg

[ Melting Point ]:
180-181ºC

[ Molecular Formula ]:
C₂₀H₂₂N₂O₃

[ Molecular Weight ]:
338.400

[ Flash Point ]:
281.0±30.1 °C

[ Exact Mass ]:
338.163055

[ PSA ]:
71.19000

[ LogP ]:
3.53

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.652

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZB1740000

CHEMICAL NAME :: Vobasan-17-oic acid, 4-demethyl-3-oxo-, methyl ester

CAS REGISTRY NUMBER :: 2673-40-7

BEILSTEIN REFERENCE NO. :: 0046952

LAST UPDATED :: 199707

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H22-N2-O3

MOLECULAR WEIGHT :: 338.44

WISWESSER LINE NOTATION :: T E6 D586 A KM NV PY RM&&TTJ AVO1 PU2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: 33GVAL "Catharanthus Alkaloids," Taylor, W.I., and N.R. Farnsworth, eds., New York, Marcel Dekker, 1975 Volume(issue)/page/year: -,73,1975

Safety Information

[ Hazard Codes ]:
Xi