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Bcl-2/Mcl-1-IN-2

Names

[ CAS No. ]:
2673361-07-2

[ Name ]:
Bcl-2/Mcl-1-IN-2

Biological Activity

[Description]:

Bcl-2/Mcl-1-IN-2 (compound 2) is a Bcl-2/Mcl-1 inhibitor, with Kis of 0.88 μM and 4.70 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-2 can be used for the research of cancer[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[Target]

Mcl-1:0.88 μM (Ki)

Bcl-2:4.70 μM (Ki)


[References]

[1]. Niu Q, et, al. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold. Bioorg Med Chem Lett. 2021 Sep 1;47:128215.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H24ClNO3

[ Molecular Weight ]:
433.93

Related Compounds