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FGFR2-IN-2

Names

[ CAS No. ]:
2677709-81-6

[ Name ]:
FGFR2-IN-2

Biological Activity

[Description]:

FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor with IC50s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

FGFR2:29 nM (IC50)

FGFR1:389 nM (IC50)

FGFR3:758 nM (IC50)

[References]

[1]. Lewis D Turner, et al. From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J Med Chem. 2022 Jan 27;65(2):1481-1504.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₂N₄O

[ Molecular Weight ]:
370.45

Related Compounds