1,3,5(10)-Estratrien-3,4,17beta-triol 4-methyl ether

Names

[ Name ]:
1,3,5(10)-Estratrien-3,4,17beta-triol 4-methyl ether

[Synonym ]:
4-Methoxyestrone
4-Hydroxyestrone-4-methyl ether
4-methoxy-E1
4-methoxy-E2

Biological Activity

[Description]:

4-Methoxyestradiol is methoxylestradiol that induces oxidative DNA damage in human lung epithelial cells. 4-Methoxyestradiol also elevates ROS and SOD activities in H1355 cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. Yahsin Cheng, et al. 4-Methoxyestradiol-induced oxidative injuries in human lung epithelial cells. Toxicol Appl Pharmacol. 2007 May 1;220(3):271-7.

Chemical & Physical Properties

[ Density]:
1.178g/cm3

[ Boiling Point ]:
472ºC at 760mmHg

[ Molecular Formula ]:
C₁₉H₂₆O₃

[ Molecular Weight ]:
302.40800

[ Flash Point ]:
239.2ºC

[ Exact Mass ]:
302.18800

[ PSA ]:
49.69000

[ LogP ]:
3.61780

[ Vapour Pressure ]:
1.03E-09mmHg at 25°C

[ Index of Refraction ]:
1.586

1,3,5(10)-Estratrien-3,4,17beta-triol 4-methyl ether

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream