Indoramin

Names

[ Name ]:
Indoramin

[Synonym ]:
3-<2-(4-Benzamidopiperid-1-yl)ethyl>indol
Indoramine [INN-French]
N-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-benzamide
3-[2-(4-benzamido-1-piperidyl)ethyl]indole
INDORAMIN
Indoramine
3-[2-(4-benzamidopiperid-1-yl)ethyl]indole
Indoramina [INN-Spanish]
EINECS 248-041-5
Benzamide,N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)
Indoraminum [INN-Latin]

Biological Activity

[Description]:

Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[References]

[1]. M Eltze, et al. In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73.

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
600ºC at 760mmHg

[ Melting Point ]:
208-210°

[ Molecular Formula ]:
C₂₂H₂₅N₃O

[ Molecular Weight ]:
347.45300

[ Flash Point ]:
316.7ºC

[ Exact Mass ]:
347.20000

[ PSA ]:
48.13000

[ LogP ]:
3.93360

[ Vapour Pressure ]:
2.36E-14mmHg at 25°C

[ Index of Refraction ]:
1.657

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV5395900

CHEMICAL NAME :: Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-

CAS REGISTRY NUMBER :: 26844-12-2

BEILSTEIN REFERENCE NO. :: 0494035

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H25-N3-O

MOLECULAR WEIGHT :: 347.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971

Safety Information

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%