ER-001259851-000

Names

[ Name ]:
ER-001259851-000

Biological Activity

[Description]:

ER-001259851-000 is a potent, selective, orally active Axl inhibitor with IC50 of 5.2 nM in cell free assays, displays >35-fold selectivity against Mer (IC50=190 nM).ER-001259851-000 shows a promising pharmacokinetic profile in mice.

[References]

1. Satoshi Inoue, et al. Bioorg Med Chem Lett. 2021 Sep 15;48:128247.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₄₁FN₈O₄

[ Molecular Weight ]:
668.774

Related Compounds

ER D8
ER 27319 maleate
ER 50891
er-878705
(E)-N-[4-[(1-benzylpiperidin-4-yl)sulfamoyl]phenyl]-N-methyl-3-(4-methylsulfonylphenyl)prop-2-enamide
er(fod)3
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-Dichloromethyl-3-methoxybenzene
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
3'-Mercapto-2'-(trifluoromethoxy)acetophenone
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
Methyl 2,3,3-trimethylcyclobut-1-ene-1-carboxylate
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde