CYP1B1-IN-4

Names

[ Name ]:
CYP1B1-IN-4

Biological Activity

[Description]:

CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

[Target]

CYP1B1:0.2 nM (IC50)

CYP1A1:3.98 μM (IC50)

[In Vitro]

CYP1B1-IN-4 (化合物15) (100 μM; 37 ℃; 0-60 min) 在人和大鼠肝微粒体中均具有体外稳定性，而在小鼠肝微粒体中稳定性较低[1]。 CYP1B1-IN-4 (1 nM-10 μM) 抑制 CYP1A1, IC50 为 3.82 μM[1]。 Cyp1b1-IN-4 (100 μM; 72 h) 对 HEK293 细胞无细胞毒性[1]。

[References]

[1]. Hachey AC, et al. Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach. J Med Chem. 2022 Dec 15.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₄N₂O₂S

[ Molecular Weight ]:
322.38

CYP1B1-IN-4

Names

Biological Activity

Chemical & Physical Properties

Related Compounds