ADAMTS-5-IN-3

Names

[ Name ]:
ADAMTS-5-IN-3

Biological Activity

[Description]:

ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[References]

[1]. Dong Liu, et al. Adamts inhibitors, preparation methods and medicinal uses thereof. WO2021158626A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₃Cl₂N₃O₃

[ Molecular Weight ]:
424.32

ADAMTS-5-IN-3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds