N-(4-(2-benzimidazolyl)phenyl)maleimide

Names

[ Name ]:
N-(4-(2-benzimidazolyl)phenyl)maleimide

[Synonym ]:
EINECS 248-173-3
N-[4-(2-benzimidazolyl)phenyl]-maleimide
1H-Pyrrole-2,5-dione, 1-[4-(1H-benzimidazol-2-yl)phenyl]-
N-[4-(1H-benzoimidazol-2-yl)-phenyl]-maleimide
1-[4-(1H-Benzimidazol-2-yl)phenyl]-1H-pyrrole-2,5-dione
MFCD00042767
BIPM
N-[p-(2-benzimidazolyl)phenyl]maleimide
N-<p-(2-Benzimidazolyl)phenyl>maleinimid
N-(4-(2-benzimidazolyl)phenyl)maleimide
N-[4-(2-Benzimidazolyl)phenyl]maleimide

Biological Activity

[Description]:

N-[4-(2-Benzimidazolyl)phenyl]maleimide is a potent fluorescent probe with excitation maximum of 315 nm and emission maximum of 360 nm. N-[4-(2-Benzimidazolyl)phenyl]maleimide can be used for fluorometry of thiol compounds[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Tanaka F, et, al. Determination of cysteine concentration by fluorescence increase: reaction of cysteine with a fluorogenic aldehyde. Chem Commun (Camb). 2004 Aug 7;(15):1762-3.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
556.3±52.0 °C at 760 mmHg

[ Melting Point ]:
247ºC

[ Molecular Formula ]:
C₁₇H₁₁N₃O₂

[ Molecular Weight ]:
289.288

[ Flash Point ]:
290.3±30.7 °C

[ Exact Mass ]:
289.085114

[ PSA ]:
66.06000

[ LogP ]:
2.12

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.742

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS03, GHS05, GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H272-H301-H312-H314-H317-H330-H334-H340-H350-H360FD-H372-H410

[ Precautionary Statements ]:
P201-P210-P260-P284-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P308 + P313-P403 + P233

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
UN3086 - class 6.1 - PG 1 - PIH - RQ - Toxic solids, oxidizing, n.o.s., HI: all

[ RTECS ]:
HX7750000

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Conformational change accompanying formation of oligomycin-induced Na(+)-bound forms and their conversion to ADP-sensitive phosphoenzymes in Na+,K(+)-ATPase.

J. Biochem. 109(2) , 299-306, (1991)

Oligomycin reduced the fluorescence intensity of an N-(p-(2-benzimidazoly)phenyl) maleimide (BIPM) probe at Cys-964 of the alpha-chain of pig kidney Na+,K(+)-ATPase with increase in the concentration ...

Different susceptibility to phospholipase A2 treatment of the fluorescence intensity changes in the vicinity of Cys-964 and Lys-501 in the alpha-chain of probe-labeled Na+,K(+)-ATPase.

J. Biochem. 115(3) , 454-62, (1994)

Phospholipase A2 [EC 3.1.1.4] treatment of pig kidney Na+,K(+)-ATPase [EC 3.6.1.3] labeled with fluorescence probes at the alpha-chain reduced the extent of the fluorescence intensity change of an N-[...

ATP-induced dynamic fluorescence changes of a N-[p-(2-benzimidazolyl)phenyl]maleimide probe at Cys241 in the alpha-chain of pig stomach H+,K+-ATPase.

J. Biochem. 122(3) , 659-65, (1997)

H+,K+-ATPase preparations from pig stomach were modified with a sulfhydryl fluorescence reagent, N-[p-(2-benzimidazolyl)phenyl] maleimide (BIPM). The addition of ATP to the modified enzyme preparation...