Anti-inflammatory agent 22

Names

[ CAS No. ]:
2721484-76-8

[ Name ]:
Anti-inflammatory agent 22

Biological Activity

[Description]:

Anti-inflammatory agent 22 (compound 14a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 22 inhibits LPS-induced TNF-α production with an IC50 value of 14.6 μM. Anti-inflammatory agent 22 has preventive effects on lymphedematous tissue via suppression of adipogenesis. Anti-inflammatory agent 22 suppresses limb lymphedema volume in mice[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

TNF-α:14.6 μM (IC50)


[References]

[1]. Roh K, et al. Synthesis and evaluation of butein derivatives for in vitro and in vivo inflammatory response suppression in lymphedema. Eur J Med Chem. 2020;197:112280.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H16O6

[ Molecular Weight ]:
376.36

Related Compounds