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8-iso Prostaglandin E2

Names

[ CAS No. ]:
27415-25-4

[ Name ]:
8-iso Prostaglandin E2

[Synonym ]:
l-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
(5E,13E)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
5-Heptenoic acid, 7-[3-hydroxy-2- (3-hydroxy-1-octenyl)-5-oxocyclopentyl]-
(5Z,8β,11α,12ξ,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-
7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
(5E)-7-{3-Hydroxy-2-[(1E)-3-hydroxy-1-octen-1-yl]-5-oxocyclopentyl}-5-heptenoic acid
Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,8β,11α,12ξ,13E,15S)-
5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-, l-
Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5E,13E)-
7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid

Biological Activity

[Description]:

8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A2 (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[References]

[1]. Wilson SJ, et al. Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signaling. Biochem Biophys Res Commun. 2007;352(2):397-403.

[2]. Tintut Y, et al. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway. J Biol Chem. 2002;277(16):14221-14226.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
530.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H32O5

[ Molecular Weight ]:
352.465

[ Flash Point ]:
288.5±26.6 °C

[ Exact Mass ]:
352.224976

[ PSA ]:
94.83000

[ LogP ]:
1.88

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.561

Related Compounds