CCG-271423

Names

[ Name ]:
CCG-271423

Biological Activity

[Description]:

CCG-271423 is a potent and selective GRK5 inhibitor with IC50 values of 0.0021 μM and 44 μM for GRK5 and GRK2, respectively. CCG-271423 inhibits cardiomyocyte contractility and decreases in Ca2+ transience[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

IC50: 0.0021 μM (GRK5) and 44 μM (GRK5)[1]

[In Vitro]

CCG-271423 (1 μM) does not alter cardiomyocyte contractility and decreases in Ca2+ transience[1].

[References]

[1]. Rowlands R, et, al. Expanding the Arsenal: Development of G-Protein Receptor Kinase 5 Inhibitors Utilizing a Covalent Strategy.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₆N₄O₃

[ Molecular Weight ]:
466.53

Related Compounds

3-N,3-N,7-N,7-N,11-N,11-N,3,7,11-nonamethyl-1,2,5,6,9,10-hexathiacyclododecane-3,7,11-tricarboxamide
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